Reinforced concrete frames infilled with masonry panels constitute an important part of the high-risk structures in different regions of high seismicity. In some developing countries, they are still used as main structural system for low to medium rise buildings. Consequently, reliable methods to analyse infilled frames are required in order to reduce the loss of life and property associated with a possible structural failure. The equivalent strut model, proposed in the 1960s, is a simple procedure to represent the effect of the masonry panel. Several improvements of the original model have been proposed, as a result of a better understanding of the behaviour of these structures and the development of computer software. This paper presents a new macro-model for the evaluation of the global response of the structure, which is based on a multi-strut formulation,. The model, implemented as 4-node panel element, accounts separately for the compressive and shear behaviour of masonry using a double truss mechanism and a shear spring in each direction. The principal premises in the development of the model are the rational consideration of the particular characteristics of masonry and the adequate representation of the hysteretic response. Furthermore, the model is able to represent different modes of failure in shear observed for masonry infills. The comparison of analytical results with experimental data showed that the proposed model, with a proper calibration, is able to represent adequately the in-plane response of infilled frames.